I could just remember how my father used to say that the reason for living was to get ready to stay dead a long time.
U.N. Women was created due to the acknowledgement that gender equality and women's empowerment was still, despite progress, far from what it should be. Transforming political will and decisions, such as the Member States creating U.N. Women, into concrete steps towards gender equality and women's empowerment, I think is one of the main challenges.
With the modern diseases (once TB, now cancer) the romantic idea that the disease expresses the character is invariably extended to assert that the character causes the disease -- because it has not expressed itself. Passion moves inward, striking and blighting the deepest cellular recesses.