When you think of it, really there are four fundamental questions of life. You've asked them, I've asked them, every thinking person asks them. They boil down to this; origin, meaning, morality and destiny. 'How did I come into being? What brings life meaning? How do I know right from wrong? Where am I headed after I die?'
Again, you can't connect the dots looking forward; you can only connect them looking backwards. So you have to trust that the dots will somehow connect in your future. You have to trust in something - your gut, destiny, life, karma, whatever. This approach has never let me down, and it has made all the difference in my life.
There is tide in the affairs of men, which, taken at the flood, leads on to fortune; omitted, all the voyage of their life is bound in shallows and in miseries; on such a full sea we are now afloat; and we must take the current the clouds folding and unfolding beyond the horizon. when it serves, or lose our ventures.
Each one of us has some kind of vocation. We are all called by God to share in His life and in His Kingdom. Each one of us is called to a special place in the Kingdom. If we find that place we will be happy. If we do not find it, we can never be completely happy. For each one of us, there is only one thing necessary: to fulfill our own destiny, according to God's will, to be what God wants us to be.