The chief misery of the decline of the faculties, and a main cause of the irritability that often goes with it, is evidently the isolation, the lack of customary appreciation and influence, which only the rarest tact and thoughtfulness on the part of others can alleviate.

Summary

This quote suggests that one of the main reasons for the decline in one's abilities and the frustration that accompanies it is the feeling of isolation and the absence of regular recognition and impact. The quote emphasizes the importance of others' sensitivity and consideration in alleviating this situation. In simpler terms, it states that when individuals feel isolated and unappreciated, it negatively affects their well-being and exacerbates the decline of their faculties, but through genuine thoughtfulness and understanding from others, this can be mitigated.